[PDF.57ag] Molecular Mechanisms of Xeroderma Pigmentosum (Advances in Experimental Medicine and Biology)

Molecular Mechanisms of Xeroderma Pigmentosum (Advances in Experimental Medicine and Biology)

[PDF.hq68] Molecular Mechanisms of Xeroderma Pigmentosum (Advances in Experimental Medicine and Biology)

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 | #8911298 in Books |  2008-07-25 | Original language:English | PDF # 1 |  10.10 x.60 x6.70l,1.10 | File type: PDF | 166 pages

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To understand the molecular mechanisms of XP, XP mouse models have been used, and mice deficient in XPA, XPC, XPD, XPG, XPF, and XPA/CSB have been produced and analysed. A recent elegant technique of targeting gene replacement in mouse embryonic stem cells has provided researchers with the ability to generate mutant mice defective in any specific gene(s). 32 Animals generated in this way display phenotypes and symptoms of XP patients, and have provided valuable tools ...

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